Putrescine → 2-Chloro-6-[(4-aminobutyl)amino]-9-cyclopentylpurine
Reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4](Cl)[N:3]=1.[NH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH2:22]>C(N(CC)CC)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4]([NH:17][CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])[N:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Chloro-6-[(4-aminobutyl)amino]-9-cyclopentylpurine is prepared from 2,6-dichloro-9-cyclopentylpurine, 1,4-diaminobutane, and triethylamine essentially as described above in Example 1, Scheme A, step b.
Sources & evidence
- ORD record
- ord-26bf4230294f40b683087d97f9cc83ef
- Source dataset
- uspto-grants-2002_07
- Patent number
- US06413974B1
Reaction notes
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