Benzenamine, 4-(phenylmethyl)- → (4-Benzyl-phenyl)-(2-methyl-6-nitro-phenyl)-amine

HRID 222863

Reaction equation

HRID 222863 reaction equation
F[C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH2:12]([C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C([O-])(C)(C)C.[K+]>CS(C)=O>[CH2:12]([C:19]1[CH:20]=[CH:21][C:22]([NH:23][C:2]2[C:3]([N+:9]([O-:11])=[O:10])=[CH:4][CH:5]=[CH:6][C:7]=2[CH3:8])=[CH:24][CH:25]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 136914Benzenamine, 4-(phenylmethyl)-HCID 134709572-Fluoro-1-methyl-3-nitrobenzeneHCID 23665647Potassium tert-butoxide

Product 1

HCID 68834454(4-Benzyl-phenyl)-(2-methyl-6-nitro-phenyl)-amine

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The product (1.01 g) is obtained according to the method of stage 1 of Example 4, by using 1.13 g of 2-fluoro-3-methyl-nitrobenzene and 2 g of 4-benzyl-aniline in the presence of 1.31 g of potassium tert-butanolate in 30 mL of DMSO.

Sources & evidence

ORD record
ord-d458c972e6344078914415d4be3fddfb
Source dataset
uspto-grants-2012_06
Patent number
US08207373B2

Linked notes

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