Hydrazine hydrate (1:1) → 3-hydrazono-butan-2-one O-methyl oxime
Reaction equation
[CH3:1][O:2][N:3]=[C:4]([C:6](=O)[CH3:7])[CH3:5].O.[NH2:10][NH2:11]>C(O)C>[CH3:1][O:2][N:3]=[C:4]([C:6](=[N:10][NH2:11])[CH3:7])[CH3:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3 g (0.026 mol) of butane-2,3-dione mono-(O-methyl oxime) are heated at 60° C. in 20 ml of ethanol with 2.6 g (0.052 mol) of hydrazine hydrate for 1 hour. The reaction mixture is poured onto water and extracted with diethyl ether, the organic phase is dried over sodium sulphate and the solvent is distilled off in vacuo. The residue is stirred with petroleum ether and the crystals are filtered off. 1 g (29.7% of theory) of 3-hydrazono-butan-2-one O-methyl oxime is obtained.
Workup
- additionThe reaction mixture is poured onto water
- extractionextracted with diethyl ether
- dry with materialthe organic phase is dried over sodium sulphate
- distillationthe solvent is distilled off in vacuo
- filtrationthe crystals are filtered off
Sources & evidence
- ORD record
- ord-39698898b8554ed5ad459b12a5aad27a
- Source dataset
- uspto-grants-2002_07
- Patent number
- US06420362B1
Reaction notes
Loading…