Hydrogen Bromide → 113884-76-7
Reaction equation
Cl.C[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14]C)[CH:10]=[N:9][CH:8]=[CH:7]2.[BrH:16]>>[BrH:16].[OH:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[OH:14])[CH:10]=[N:9][CH:8]=[CH:7]2Participants
3
Procedure
63.4 g (0.28 mol) of 6,7-dimethoxyisoquinoline hydrochloride was dissolved in 630 ml of 47% hydrobromic acid, and the mixture was refluxed for 24 hours under stirring in nitrogen atmosphere. The reaction mixture was allowed to stand still under cooling with ice. The crystals formed were collected by filtration and washed with cold water and acetone. They were dried in air overnight and then dried at a temperature of from 90° to 95° C. for 6 hours to obtain 66.4 g (yield: 97.6%) of the above identified compound.
Workup
- temperaturethe mixture was refluxed for 24 hours
- temperatureunder cooling with ice
- customThe crystals formed
- filtrationwere collected by filtration
- washwashed with cold water and acetone
- customThey were dried in air overnight
- customdried at a temperature of from 90° to 95° C. for 6 hours
- customto obtain 66.4 g (yield: 97.6%) of the
Sources & evidence
- ORD record
- ord-b1790ec008744d5cac8ad4aa2ffd039b
- Source dataset
- uspto-grants-1988_11
- Patent number
- US04782155
Reaction notes
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