Sodium Hydroxide → 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-2-mercapto-
Reaction equation
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([CH:6]=[C:7]2[S:11]C(=S)N[C:8]2=[O:13])=[CH:4][C:3]=1[O:16][CH3:17].[OH-:18].[Na+]>Cl>[OH:1][C:2]1[CH:15]=[CH:14][C:5]([CH:6]=[C:7]([SH:11])[C:8]([OH:18])=[O:13])=[CH:4][C:3]=1[O:16][CH3:17]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The product from Step A was added to 20% sodium hydroxide solution (250 mL) and heated to 70°-75° C. with stirring for one hour. The resulting solution was chilled in an ice bath and added rapidly, with stirring, to cold 10% hydrochloric acid (350 mL). The yellow solid was collected, washed with water and dried at 50° C.; yield 36 g.
Workup
- temperatureheated to 70°-75° C.
- temperatureThe resulting solution was chilled in an ice bath
- additionadded rapidly
- customThe yellow solid was collected
- washwashed with water
- customdried at 50° C.
Sources & evidence
- ORD record
- ord-ec4604586f234c3195d83d93c2475c93
- Source dataset
- uspto-grants-1988_11
- Patent number
- US04788192
Reaction notes
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