HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Chloropropyl)-4-phenylpiperidine → 7-methoxy-4-(1-methylethyl)-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Chloropropyl)-4-phenylpiperidine | HCID 203689 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 6-hydroxy-7-methoxy-4-(1-methylethyl)-2H-1-benzopyran-2-one | HCID 19927654 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 7-methoxy-4-(1-methylethyl)-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927638 | 85% |
Reaction Steps
Method D (2.5 h at 85° C.); starting materials: 6-hydroxy-7-methoxy-4-(1-methylethyl)-2H-1-benzopyran-2-one (example 105) and 1-(3-chloropropyl)-4-phenyl-piperidine; yield 85%; fusion point 62°-65° C. (from TBME). Fumarate: method E; yield 65%; fusion point 155°-157° C. (from acetone, boiled out with TBME).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-13dfe9d867b84ecfb63a521715149af8 |
| Source note | uspto-grants-1995_06 |