反应详情

Method D (2.5 h at 85° C.); starting materials: 6-hydroxy-7-methoxy-4-(1-methylethyl)-2H-1-benzopyran-2-one (example 105) and 1-(3-chloropropyl)-4-phenyl-piperidine; yield 85%; fusion point 62°-65° C. (from TBME). Fumarate: method E; yield 65%; fusion point 155°-157° C. (from acetone, boiled out with TBME).

1. customMethod D (2.5 h at 85° C.)
2. customfusion point 155°-157° C.