Ammonium Hydroxide → 9-[2-(1,4-Benzodioxan-2-yl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
Reaction equation
Cl.[O:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][CH2:4][CH:3]1[CH2:12][CH2:13][N:14]1[CH2:25][CH2:24][C:17]2([O:22][CH2:21][C:20](=[O:23])[NH:19][CH2:18]2)[CH2:16][CH2:15]1.[OH-].[NH4+]>O>[O:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][CH2:4][CH:3]1[CH2:12][CH2:13][N:14]1[CH2:25][CH2:24][C:17]2([O:22][CH2:21][C:20](=[O:23])[NH:19][CH2:18]2)[CH2:16][CH2:15]1Participants
4
Procedure
A solution of 3.5 g of 9-[2-(1,4-benzodioxan-2-yl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride salt in water (50 ml) was adjusted to pH 12 with ammonium hydroxide solution and extracted with methylene chloride. The methylene chloride was evaporated to afford 3 g of 9-[2-(1,4-benzodioxan-2-yl)ethyl]-1-oxa-4,9-diazaspiro-[5.5]undecan-3-one as the free base, mp 139°-140° C.