Hydrazine hydrate (1:1) → 2,3-Dihydro-3-oxo-6-(4-pyridinyl)-4-pyridazinecarboxylic acid hydrazide

HRID 2234098

Reaction equation

HRID 2234098 reaction equation
C([O:3][C:4]([C:6]1[C:7](=[O:18])[NH:8][N:9]=[C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[CH:11]=1)=O)C.O.[NH2:20][NH2:21]>C(O)C>[O:18]=[C:7]1[C:6]([C:4]([NH:20][NH2:21])=[O:3])=[CH:11][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:9][NH:8]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12790231Ethyl 3-oxo-6-(pyridin-4-yl)-2,3-dihydropyridazine-4-carboxylate

Product 1

HCID 127902392,3-Dihydro-3-oxo-6-(4-pyridinyl)-4-pyridazinecarboxylic acid hydrazide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 g of 3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazine-4-carboxylic acid ethyl ester are dissolved in 150 ml of ethanol, 4.2 ml of hydrazine hydrate is added and the mixture is refluxed for 5 hours. After cooling to room temperature, the solid is collected by filtration and dried in vacuo at 40° C.

Workup

  1. temperaturethe mixture is refluxed for 5 hours
  2. filtrationthe solid is collected by filtration
  3. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-8c227b6eb2e6458ca2566fd274b63e83
Source dataset
uspto-grants-2010_05
Patent number
US07709466B2

Linked notes

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