Methanol → 3-(Isopropylamino)-N-methylpropanamide

Temperature

140 °C

Isopropylamine (Aldrich; 1.5 ml, 17.62 mmol) and methyl acrylamide (ABCR; 1.0 g, 11.75 mmol) were combined in methanol (10 ml). The mixture was heated in a microwave at 140° C. for 30 min. The reaction was repeated and the combined reaction mixtures were concentrated to remove excess amine. The residue was re-dissolved in methanol and absorbed onto an SCX column (50 g), washed with methanol and eluted with ammonia/methanol. Concentration of the product containing fractions gave the title compound as a colourless oil (3.2 g, 94%).

1. customthe combined reaction mixtures
2. concentrationwere concentrated
3. customto remove excess amine
4. dissolutionThe residue was re-dissolved in methanol
5. customabsorbed onto an SCX column (50 g)
6. washwashed with methanol
7. washeluted with ammonia/methanol
8. additionConcentration of the product containing fractions

ORD record

ord-e0fba4985bad43ddb524ea13723d60df

Source dataset

uspto-grants-2010_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07709471B2