Hydrochloric Acid → (3R)-1-Methyl-3-PyrrolidinaMine hydrochloride
Reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][C@@H:4]([NH:7]C(=O)OC(C)(C)C)[CH2:3]1.[ClH:15]>O1CCOCC1>[ClH:15].[ClH:15].[CH3:1][N:2]1[CH2:6][CH2:5][C@@H:4]([NH2:7])[CH2:3]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
tert-butyl N-[(3R)-1-methylpyrrolidin-3-yl]carbamate (Intermediate 185; 1.18 g, 5.67 mmol) was dissolved in 1,4-dioxane (10 mL) and 4M HCl in dioxane (10 mL) added. The mixture was stirred at room temperature for 1 hour and then concentrated to yield the title compound as a white hygroscopic solid (810 mg, 100%).
Workup
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-aef1212eac7d477da2f0730538cbdad5
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07709471B2
Reaction notes
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