Potassium Carbonate → HCID 178516223, compound

Reaction equation

[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C@@H:7]1[CH2:12][CH2:11][C@H:10]([O:13]C(=O)C2C=CC([N+]([O-])=O)=CC=2)[CH2:9][CH2:8]1.C(=O)([O-])[O-].[K+].[K+]>CO.O>[OH:13][C@@H:10]1[CH2:9][CH2:8][C@H:7]([N:3]2[CH2:4][CH2:5][CH2:6][C:2]2=[O:1])[CH2:12][CH2:11]1

Participants

Procedure

Dissolve cis-4-nitro-benzoic acid 4-(2-oxo-pyrrolidin-1-yl)-cyclohexyl ester (Preparation 15) (87.9 g; 264 mmol) in methanol (1.35 L) and water (150 mL) and add potassium carbonate (109.5 g; 800 mmol). Stir at room temperature overnight to give a white precipitate. Evaporate to dryness. Azeotrope with ethanol (×2). Stir in tetrahydrofuran (1 L) for 1 hour then filter. Evaporate the filtrate to an oil and crystallize from diethyl ether (100 mL) to afford 40 g (83%) of the title compound.