Hydrogen Bromide → 6-Methoxy-3-(piperidin-4-yl)-1,2-benzoxazole--hydrogen bromide (1/1)
Reaction equation
[BrH:1].C1(COC([N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[C:22]4[CH:23]=[CH:24][C:25]([O:27][CH3:28])=[CH:26][C:21]=4[O:20][N:19]=3)[CH2:14][CH2:13]2)=O)C=CC=CC=1>C(O)(=O)C>[BrH:1].[CH3:28][O:27][C:25]1[CH:24]=[CH:23][C:22]2[C:18]([CH:15]3[CH2:14][CH2:13][NH:12][CH2:17][CH2:16]3)=[N:19][O:20][C:21]=2[CH:26]=1Participants
4
Procedure
To 30 ml of a saturated solution of hydrogen bromide and acetic acid was added, with stirring, 0.88 g of 4-(6-methoxy-1,2-benzisoxazol-3-yl)-1-piperidine carboxylic acid phenylmethyl ester. The reaction was stirred at ambient temperature for 55 min. The resultant solid was collected, washed with ether and dried to yield 0.5 g (79.8%) of product. Recrystallization from methanol gave the analytical sample, mp 258°-260°.