Oxalyl chloride → 4-Chloro-3-hydroxybenzoyl chloride

HRID 2236520Notes

Reaction equation

HRID 2236520 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[OH:11].C(Cl)(=O)C([Cl:15])=O>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[CH:4][C:3]=1[OH:11]

Participants

3

Reactant 2

HCID 65578Oxalyl chlorideHCID 1418724-Chloro-3-hydroxybenzoic acid

Product 1

HCID 754648184-Chloro-3-hydroxybenzoyl chloride

Conditions

Temperature
60 °C

Procedure

An amount of 1 g (5.57 mmol) of 4-chloro-3-hydroxy benzoic acid is added 10 ml (115.8 mmol) of oxalyl chloride and refluxed at 60° C. till the solid had gone into solution. After cooling, the mixture is evaporated to dryness to give 4-chloro-3-hydroxy-benzoyl chloride.

Workup

  1. temperatureAfter cooling
  2. customthe mixture is evaporated to dryness

Sources & evidence

ORD record
ord-16e6a048a2ed40ebae9f8496b1802c19
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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