[C:1]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[CH2:9][S:10][C:11]1[CH:12]=[C:13]([CH:17]([CH3:23])[C:18]([O:20]CC)=[O:19])[CH:14]=[CH:15][CH:16]=1)#N.[OH-:24].[K+].Cl.[OH2:27]>C(O)COCCO>[C:1]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[CH2:9][S:10][C:11]1[CH:12]=[C:13]([CH:17]([CH3:23])[C:18]([OH:20])=[O:19])[CH:14]=[CH:15][CH:16]=1)([OH:27])=[O:24]The above ester compound (2.6 g) was added to a solution of potassium hydroxide (2.6 g) in water (5 ml) and diethylene glycol (8 ml) and the mixture was heated with stirring for 5.5 hours in an oil bath maintained at 250° C. The reaction mixture was poured into water, acidified with hydrochloric acid and extracted with ethyl acetate. The ethyl acetate layers were washed with water, dried over anhydrous sodium sulfate and evaporated to dryness under reduced pressure to give the title compound (2.5 g) as an oil. IRνmaxfilm cm-1 : 1700 (C=O). MS m/e: 322 (M+).
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