3-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one → 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one
Reaction equation
[C:1]([C:5]1[N:6]([CH3:24])[C:7](=[O:23])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11]([O:21]C)=[CH:10][CH:9]=2)([CH3:4])([CH3:3])[CH3:2]>Br>[C:1]([C:5]1[N:6]([CH3:24])[C:7](=[O:23])[C:8]2[C:13]([C:14]=1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[CH:12][C:11]([OH:21])=[CH:10][CH:9]=2)([CH3:4])([CH3:2])[CH3:3]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 3-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one (0.333 g) and 48% HBr (30 mL) was heated at reflux for 8 h. The reaction was concentrated to give 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one as a brown solid, which was used without further purification.
Workup
- temperaturewas heated
- temperatureat reflux for 8 h