1-Methyl-4-nitro-1H-pyrrolo[2,3-b]pyridine → 1-Methyl-1H-pyrrolo[2,3-b]pyridin-4-amine
Reaction equation
[CH3:1][N:2]1[C:6]2=[N:7][CH:8]=[CH:9][C:10]([N+:11]([O-])=O)=[C:5]2[CH:4]=[CH:3]1.[H][H]>C(O)C.C1COCC1.[Pt](=O)=O>[CH3:1][N:2]1[C:6]2[N:7]=[CH:8][CH:9]=[C:10]([NH2:11])[C:5]=2[CH:4]=[CH:3]1Participants
5
Procedure
300 mg (1.69 mmol) of 1-methyl-4-nitro-1H-pyrrolo[2,3-b]pyridine are dissolved in a mixture of 20 ml of ethanol/THF (1:1). 38 mg (0.17 mmol) of platinum(IV) oxide are added, and the mixture is hydrogenated in a hydrogen atmosphere at atmospheric pressure overnight. The mixture is filtered through Celite and the solvent is removed under reduced pressure.
Workup
- filtrationThe mixture is filtered through Celite
- customthe solvent is removed under reduced pressure
Sources & evidence
- ORD record
- ord-0345f99d768646219f4c1f289a99ff1a
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07723347B2
Reaction notes
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