HCID 69242804, compound → HCID 11675251, compound
Reaction equation
C(OC([N:8]1[CH2:12][C@@H:11]([CH2:13][NH:14][C:15](=[O:26])[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([O:24][CH3:25])=[O:23])[CH:17]=2)[CH2:10][C@H:9]1[C:27]([N:29]1[CH2:33][CH2:32][S:31][CH2:30]1)=[O:28])=O)(C)(C)C>Cl.O1CCOCC1>[CH3:25][O:24][C:22](=[O:23])[C:18]1[CH:19]=[CH:20][CH:21]=[C:16]([C:15]([NH:14][CH2:13][C@H:11]2[CH2:10][C@@H:9]([C:27]([N:29]3[CH2:33][CH2:32][S:31][CH2:30]3)=[O:28])[NH:8][CH2:12]2)=[O:26])[CH:17]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of Example 18A (100 mg) in 4 M HCl in dioxane (2 mL) was stirred at room temperature for 16 hours, and concentrated under reduced pressure. The residue was taken up and concentrated under reduced pressure under the following solvents, methanol (10 mL), ether (10 mL) and dichloromethane (10 mL) to provide the titled compound as a pale yellow solid. MS (ESI) m/e 378 (M+H)+; 1H NMR (500 MHz, CD3OD): δ ppm 1.80 (m, 1 H), 2.74 (m, 1 H), 2.82 (m, 1 H), 3.09 (m, 1 H), 3.16 (q, 1 H), 3.23 (dd, 1 H), 3.33 (m, 1 H), 3.56 (m, 3 H), 3.74 (m, 1 H), 3.88 (m, 1 H), 3.93 (d, 3 H), 4.52 (m, 1 H), 4.67 (m, 2 H), 7.61 (m, 1 H), 8.07 (m, 1 H), 8.19 (d, 1 H), 8.49 (m, 1 H).