Reaction equation
Cl[C:2]1[C:12]2[C:11]3[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=3[S:9][N:8]=[CH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[N:17]1([C:2]2[C:12]3[C:11]4[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=4[S:9][N:8]=[CH:7][C:6]=3[CH:5]=[CH:4][CH:3]=2)[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1Participants
Procedure
EP 0282236-A1 reports that a dibenzothiazepine derivative can be processed to give 11-[4-(2-(2-hydroxyethoxy)-ethyl]-1-piperadinyldibenzothiazepine derivative, which is of value as, for example, an antipsychotic pharmaceutical. In more detail, dibenzo-[b,f][1,4]thiazepin-11-one, which is a representative compound of the dibenzothiazepine derivatives reported therein, is reacted with phosphorus oxychloride to yield a 11-chloro-dibenzothiazepine derivative. To the 11-chloro-dibenzothiazepine derivative is added piperazine to yield a 11-piperazinyl-dibenzothiazepine derivative, which is subsequently reacted with 2-chloroethoxyethanol under basic conditions to give the desired 11-[4-(2-(2-hydroxyethoxy)-ethyl]-1-piperadinyldibenzothiazepin.
Sources & evidence
- ORD record
- ord-2d862b37df804e9bad6a8326a0dedb8e
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07671195B2
Linked notes
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