Water → 4-Amino-3-bromobenzoic acid
Reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[Br:11]N1C(=O)CCC1=O.O>CN(C=O)C>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[Br:11]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
4-Amino-benzoic acid (100 mmol) was dissolved in DMF (50 mL) and N-bromosuccinimide (100 mmol) was added. Stirred at ambient temperature for 18 h, the reaction mixture was then poured into water (100 mL). The product was removed by filtration, washed with water and dried in vacuo to give 4-amino-3-bromo-benzoic acid.
Workup
- customThe product was removed by filtration
- washwashed with water
- customdried in vacuo
Sources & evidence
- ORD record
- ord-0bb57b91eb7849a5baba823937559782
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07674912B2
Reaction notes
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