Hydrazine hydrate (1:1) → 3-(5-Fluoro-2-trifluoromethyl-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine
Reaction equation
[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=O.COP([CH2:17][C:18]([C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[C:27]([F:30])([F:29])[F:28])=O)(=O)OC.O.[NH2:32][NH2:33]>>[F:26][C:24]1[CH:23]=[CH:22][C:21]([C:27]([F:30])([F:29])[F:28])=[C:20]([C:18]2[N:33]=[N:32][C:2]3[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:1]=3[CH:17]=2)[CH:25]=1Participants
4
Procedure
yellow oil. MS (EI): 324.2 (M+). Prepared from cyclooctane-1,2-dione, [2-(5-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.