Hydrazine hydrate (1:1) → 3-(1-Methyl-1H-pyrrol-2-yl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

Reaction equation

[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=O.COP([CH2:17][C:18]([C:20]1[N:21]([CH3:25])[CH:22]=[CH:23][CH:24]=1)=O)(=O)OC.O.[NH2:27][NH2:28]>>[CH3:25][N:21]1[CH:22]=[CH:23][CH:24]=[C:20]1[C:18]1[N:28]=[N:27][C:2]2[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:1]=2[CH:17]=1

Participants

Reactant 3

HCID 24654Hydrazine hydrate (1:1)

HCID 5436981,2-Cyclooctanedione

HCID 86609923[2-(1-Methyl-1H-pyrrol-2-yl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 160637073-(1-Methyl-1H-pyrrol-2-yl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

Procedure

off-white solid. MS (ESI): 241.2 (M+). Prepared from cyclooctane-1,2-dione, [2-(1-Methyl-1H-pyrrol-2-yl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record: ord-096a070499a04dc18a914793e1beb5e0
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07678795B2

Reaction notes

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