Ethylenediamine → HCID 68544128, compound
Reaction equation
Br[CH2:2][CH2:3][N:4]1[CH:8]=[CH:7][CH:6]=[N:5]1.[CH2:9]([NH2:12])[CH2:10][NH2:11]>O1CCCC1.O>[N:4]1([CH2:3][CH2:2][N:11]=[CH:10][CH2:9][NH2:12])[CH:8]=[CH:7][CH:6]=[N:5]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 1-(2-bromoethyl)pyrazole [6d] (12 mmol) in tetrahydrofuran was added dropwise to a solution of ethylenediamine (0.24 mol) in water. The mixture was refluxed for 4 hours. The THF was removed under vacuum and the water phase was washed with dichloromethane. After drying under vacuum resulted a yellow oil which was formulated as pz(CH2)2NH(CH2)2NH2 (1). Yield: 50%
Workup
- temperatureThe mixture was refluxed for 4 hours
- customThe THF was removed under vacuum
- washthe water phase was washed with dichloromethane
- customAfter drying under vacuum
- customresulted a yellow oil which
Sources & evidence
- ORD record
- ord-7c8eda593d6c4b59a76a846090f7cdc6
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07682601B2
Reaction notes
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