Dichloromethane → HCID 68687298, compound
Reaction equation
[CH3:1][O:2][C:3]([C@H:5]1[C@@H:10]([NH2:11])[CH2:9][CH2:8][N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:6]1)=[O:4].C(Cl)Cl.CCN([CH2:27][CH3:28])CC>>[CH3:1][O:2][C:3]([C@H:5]1[C@@H:10]([NH:11][C:3]([O:2][CH2:1][C:28]2[CH:27]=[CH:9][CH:10]=[CH:5][CH:6]=2)=[O:4])[CH2:9][CH2:8][N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:6]1)=[O:4]Participants
4
Procedure
(3R,4S)-4-Amino-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (540 mg, synthesized according to Duan, Jingwu et al, PCT Int. Appl. (2001), WO 2001070673 A2) and WO 2002002525) was dissolved in abs. DCM and NEt3 (0.39 ml) was added.
Sources & evidence
- ORD record
- ord-54a6637751ed42aeb3c2f4876f8ef097
- Source dataset
- uspto-grants-2010_03
- DOI