5,6-Diamino-3-methyl-1-phenyluracil → 3,7-dihydro-1-methyl-3-phenyl-8-propyl-1H-purine-2,6-dione

HRID 224585

Reaction equation

HRID 224585 reaction equation
[NH2:1][C:2]1[C:3](=[O:17])[N:4]([CH3:16])[C:5](=[O:15])[N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:7]=1[NH2:8]>C(OC(=O)CCC)(=O)CCC>[CH3:16][N:4]1[C:3](=[O:17])[C:2]2[NH:1][C:14]([CH2:9][CH2:10][CH3:11])=[N:8][C:7]=2[N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]1=[O:15]

Participants

3

Reactant 1

HCID 110752755,6-Diamino-3-methyl-1-phenyluracil

Product 1

HCID 233316783,7-dihydro-1-methyl-3-phenyl-8-propyl-1H-purine-2,6-dione

Reagents, catalysts & solvents 1

HCID 7798Butyric anhydrideSolvent

Procedure

A solution of 3 g of 5,6-diamino-3-methyl-1-phenyl-2,4-(1H, 3H)-pyrimidinedione XVIII in 25 ml of butyric anhydride was refluxed for 16 hours. After cooling, grey crystals were filtered off and recrystallized from 100 ml of ethanol. Yield 1.1 g NMR.

Workup

  1. temperatureAfter cooling
  2. filtrationgrey crystals were filtered off
  3. customrecrystallized from 100 ml of ethanol

Sources & evidence

ORD record
ord-7bb604bf4dae465d9037e14ba509730b
Source dataset
uspto-grants-1980_11
Patent number
US04233303

Linked notes

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