Hydroxylamine → 2-Chloro-N'-hydroxy-4-[(methylsulfonyl)amino]benzenecarboximidamide

HRID 2246233Notes

Reaction equation

HRID 2246233 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][S:11]([CH3:14])(=[O:13])=[O:12])[CH:5]=[CH:6][C:7]=1[C:8]#[N:9].[NH2:15][OH:16]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][S:11]([CH3:14])(=[O:13])=[O:12])[CH:5]=[CH:6][C:7]=1[C:8](=[N:15][OH:16])[NH2:9]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 669685N-(3-chloro-4-cyanophenyl)methanesulfonamide

Product 1

HCID 725337992-Chloro-N'-hydroxy-4-[(methylsulfonyl)amino]benzenecarboximidamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

To a stirred solution of the product from Step A (0.13 g, 0.565 mmol) in ethanol (3 mL) was added hydroxylamine (50% in water, 1.0 mL). The reaction was heated at 90° C. for 2 h. The reaction was then concentrated to give the desired product.

Workup

  1. concentrationThe reaction was then concentrated

Sources & evidence

ORD record
ord-29c660b8b31b4cfb89eb3c7c518f418c
Source dataset
uspto-grants-2010_03
Patent number
US07687492B2

Reaction notes

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