Isopropanol → (6-Isopropoxy-quinazolin-4-yl)-pyrazin-2-yl-amine

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:13][C:14]1[CH:19]=[N:18][CH:17]=[CH:16][N:15]=1.[CH3:20][CH:21](O)[CH3:22]>>[CH:21]([O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:13][C:14]1[CH:19]=[N:18][CH:17]=[CH:16][N:15]=1)([CH3:22])[CH3:20]

Participants

Reactant 3

HCID 3776Isopropanol

HCID 78747Aminopyrazine

HCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160349(6-Isopropoxy-quinazolin-4-yl)-pyrazin-2-yl-amine

Procedure

The compound of Example 23 was manufactured by the same method as in Example 22, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-hydroxy-quinazoline, 2-propanol and 2-aminopyrazine.

Sources & evidence

ORD record: ord-424225978bf64f1584b395f59a406bac
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07687502B2

Reaction notes

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