Hydroxylamine → HCID 86620222, compound
Reaction equation
[Si:1]([O:8][CH2:9][C:10]1[S:14][C:13]([C:15]#[N:16])=[C:12]([CH3:17])[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[NH2:18][OH:19]>>[Si:1]([O:8][CH2:9][C:10]1[S:14][C:13]([C:15](=[N:18][OH:19])[NH2:16])=[C:12]([CH3:17])[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:2])[CH3:3]Participants
3
Procedure
The crude product of the title compound was synthesized by conducting the reaction similar to that mentioned in Example 1 (1d) using 5-({[t-butyl(dimethyl)silyl]oxy}methyl)-3-methylthiophene-2-carbonitrile (2.5 g, 9.2 mmol) that was obtained in Example 11 (11c) and a 40% aqueous solution of hydroxylamine (20 mL). Subsequently, the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (0:10 to 5:95) as the eluent to afford the title compound (1.4 g) in a yield of 52% as a white crystalline solid.
Workup
- customthe reaction similar to