Trifluoroacetic acid → HCID 86744971, compound

Reaction equation

[CH3:1][O:2][C:3](=[O:20])[CH2:4][NH:5][C:6](=[O:19])[C@H:7]([CH:16]([CH3:18])[CH3:17])[NH:8]C(OC(C)(C)C)=O.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[CH3:1][O:2][C:3](=[O:20])[CH2:4][NH:5][C:6](=[O:19])[C@H:7]([CH:16]([CH3:17])[CH3:18])[NH2:8]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 14235550N-[(1,1-Dimethylethoxy)carbonyl]-L-valylglycine methyl ester

Product 1

HCID 86744971HCID 86744971, compound

Procedure

t-butyloxycarbonyl-L-valyl-glycine methyl ester (1.44 g, 5 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was left at room temperature for 1 hour. The solution was evaporated to dryness in vacuo and the residue triturated with dry ether.

Workup

customThe solution was evaporated to dryness in vacuo
customthe residue triturated with dry ether

Sources & evidence

ORD record: ord-79272b99fddf470bb0548622df5394de
Source dataset: uspto-grants-1991_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05037957

Reaction notes

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