Phosphonic acid → 4-Methyl-2-methylene valeric acid

HRID 225101

Reaction equation

HRID 225101 reaction equation
O[CH2:2][CH:3]([CH2:7][CH:8]([CH3:10])[CH3:9])[C:4]([OH:6])=[O:5].P(=O)(O)O>>[CH3:9][CH:8]([CH3:10])[CH2:7][C:3](=[CH2:2])[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 407Phosphonic acidHCID 117893432-(Hydroxymethyl)-4-methylpentanoic acid

Product 1

HCID 1686594-Methyl-2-methylene valeric acid

Procedure

The compounds of formula I can be prepared using as a starting material 2-(hydroxymethyl)-4-methylpentanoic acid. Heating the starting material with phosphonic acid yields 4-methyl-2-methylenepentanoic acid which can in turn be reacted with a thio acid having the formula

Workup

  1. customThe compounds of formula I can be prepared

Sources & evidence

ORD record
ord-033247e2a79a440599d16fa454dc8557
Source dataset
uspto-grants-1980_11
Patent number
US04235885

Linked notes

Loading…