Phosphonic acid → 4-Methyl-2-methylene valeric acid
Reaction equation
O[CH2:2][CH:3]([CH2:7][CH:8]([CH3:10])[CH3:9])[C:4]([OH:6])=[O:5].P(=O)(O)O>>[CH3:9][CH:8]([CH3:10])[CH2:7][C:3](=[CH2:2])[C:4]([OH:6])=[O:5]Participants
3
Procedure
The compounds of formula I can be prepared using as a starting material 2-(hydroxymethyl)-4-methylpentanoic acid. Heating the starting material with phosphonic acid yields 4-methyl-2-methylenepentanoic acid which can in turn be reacted with a thio acid having the formula
Workup
- customThe compounds of formula I can be prepared
Sources & evidence
- ORD record
- ord-033247e2a79a440599d16fa454dc8557
- Source dataset
- uspto-grants-1980_11
- Patent number
- US04235885
Reaction notes
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