Dimethylformamide dimethyl acetal → 3-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

HRID 225249

Reaction equation

HRID 225249 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([C:9](=[O:12])[CH2:10][CH3:11])[CH:6]=[CH:7][CH:8]=1.CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[CH3:20][N:18]([CH3:19])[CH:17]=[C:10]([CH3:11])[C:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=1)=[O:12]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 137064Propiophenone, 3'-(trifluoromethyl)

Product 1

HCID 545299423-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

Procedure

A mixture of 25 g. of m-trifluoromethylpropiophenone and 25 ml. of dimethylformamide dimethylacetal is refluxed overnight and then evaporated to an oil. The oil is dissolved in hexane and the solution is refrigerated giving crystals of the desired product, m.p. 53°-55° C.

Workup

  1. additionA mixture of 25 g
  2. customevaporated to an oil
  3. dissolutionThe oil is dissolved in hexane

Sources & evidence

ORD record
ord-5fff47f6d35c4586a4b592f9e37d7b09
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Linked notes

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