3,4-Dimethoxyphenyl methyl ketone → (E)-1-(3,4-dimethoxyphenyl)-3-(dimethylamino)-2-propen-1-one

HRID 225279

Reaction equation

HRID 225279 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11](=[O:13])[CH3:12])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].CO[CH:16](OC)[N:17]([CH3:19])[CH3:18]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11](=[O:13])[CH:12]=[CH:16][N:17]([CH3:19])[CH3:18])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 143283,4-Dimethoxyphenyl methyl ketoneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 1481361(E)-1-(3,4-dimethoxyphenyl)-3-(dimethylamino)-2-propen-1-one

Procedure

A mixture of 50.0 g. of 3',4'-dimethoxyacetophenone and 50 ml. of dimethylformamide dimethylacetal is refluxed for 16 hours. On cooling the desired compound crystallizes from solution. Hexane is added and the material is recovered by filtration, m.p. 124°-125° C.

Workup

  1. additionA mixture of 50.0 g

Sources & evidence

ORD record
ord-54c4480f822a4aa3a9d351bb9039ec04
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Linked notes

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