O-Cresol → 6-tert-Butyl-m-cresol

HRID 225304

Reaction equation

[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:8].[CH3:9][C:10]1[C:15](O)=CC=C[CH:11]=1>>[C:10]([C:5]1[CH:4]=[CH:3][C:2]([CH3:8])=[CH:1][C:6]=1[OH:7])([CH3:15])([CH3:11])[CH3:9]

Participants

Reactant 2

HCID 335O-Cresol

HCID 342M-Cresol

Product 1

HCID 69376-tert-Butyl-m-cresolYield 95%

Procedure

Run B of Example 1 is repeated except that 3-cresol is substituted for the cresylic acid mixture. The process results in a selectivity of better than 95 percent of 6-t-butyl-3-cresol.

Sources & evidence

ORD record: ord-4a7b754a22b24add8952343199c0d9fe
Source dataset: uspto-grants-1980_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04236032

Linked notes

Loading…