1-[2-Hydroxy-4,6-bis(methoxymethoxy)phenyl]ethanone → 4-Methoxybenzaldehyde

HRID 2254263

Reaction equation

HRID 2254263 reaction equation
O[C:2]1[CH:7]=[C:6]([O:8][CH2:9]OC)[CH:5]=[C:4](OCOC)[C:3]=1[C:16](=[O:18])C>C(O)C>[CH3:9][O:8][C:6]1[CH:7]=[CH:2][C:3]([CH:16]=[O:18])=[CH:4][CH:5]=1

Participants

3

Reactant 1

HCID 108796971-[2-Hydroxy-4,6-bis(methoxymethoxy)phenyl]ethanone

Product 1

HCID 312444-MethoxybenzaldehydeYield 114.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 45 ml of ethanol were dissolved 6.00 g of the 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone obtained in Production Example 11 and 3.65 g of the p-methoxybenzaldehyde obtained in Production Example 25, and the solution was cooled to 0° C. and 55 ml of a saturated solution of potassium hydroxide in ethanol was added to the solution. The mixture was stirred for 24 hours. After the reaction, the reaction liquid was diluted with water and neutralized with 6 N hydrochloric acid, and the formed precipitate was recovered by filtration to obtain 8.17 g (yield=86.3%) of 2'-hydroxy-4,4',6'-tris(methoxymethoxy)chalcone.

Sources & evidence

ORD record
ord-6093b9f0ae964a008d8813b491a5678f
Source dataset
uspto-grants-1993_08
Patent number
US05234951

Linked notes

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