Hydrochloric Acid → 5-(4-Methyl-thiazol-2-yl)-2,3-dihydro-1H-isoindole

Reaction equation

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[S:18][CH:19]=[C:20]([CH3:22])[N:21]=3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[CH3:22][C:20]1[N:21]=[C:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[S:18][CH:19]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 577537115-(4-Methyl-thiazol-2-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 577535025-(4-Methyl-thiazol-2-yl)-2,3-dihydro-1H-isoindole

Procedure

Prepared in analogy to Example A3(e) from 5-(4-Methyl-thiazol-2-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and using trifluoacetic acid instead of hydrochloride acid. Brown solid. MS (m/e): 217.1 ([M+H]+, 100%)

Sources & evidence

ORD record: ord-4faf4fcb9369433fb726abc2d9924fb5
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557114B2

Reaction notes

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