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Triethylamine → HCID 21467139, compound

HRID 2255987
Notes
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Reaction equation

HRID 2255987 reaction equation
[Cl:1][C:2]1[CH:19]=[C:18]([NH2:20])[CH:17]=[CH:16][C:3]=1[C:4]([N:6]1[CH2:12][CH2:11][CH:10]=[CH:9][C:8]2[S:13][CH:14]=[CH:15][C:7]1=2)=[O:5].C(N(CC)CC)C.[F:28][C:29]1[CH:30]=[CH:31][C:32]([CH3:38])=[C:33]([CH:37]=1)[C:34](Cl)=[O:35]>ClCCl.O>[S:13]1[C:8]2[CH:9]=[CH:10][CH2:11][CH2:12][N:6]([C:4]([C:3]3[CH:16]=[CH:17][C:18]([NH:20][C:34](=[O:35])[C:33]4[CH:37]=[C:29]([F:28])[CH:30]=[CH:31][C:32]=4[CH3:38])=[CH:19][C:2]=3[Cl:1])=[O:5])[C:7]=2[CH:15]=[CH:14]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 27373835-Fluoro-2-methylbenzoyl chlorideHCID 21467148HCID 21467148, compound

Product 1

HCID 21467139HCID 21467139, compoundYield 74.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolvent
HCID 6344
Dichloromethane
Solvent
3×

Procedure

To a cooled solution of 0.20 g of 4-(2-chloro-4-aminobenzoyl)-5,6-dihydro-4H-thieno[3,2-b]azepine and 137 μl of triethylamine in 3 ml of dichloromethane is added a solution of 0.142 g of 5-fluoro-2-methylbenzoyl chloride in 1 ml of dichloromethane. The mixture is stirred under argon for 2 days and diluted with 30 ml of dichloromethane and 15 ml of H2O. The organic layer is separated and washed with 15 ml each of 2N citric acid, 1M NaHCO3, brine and dried (Na2SO4). The solution is filtered through a thin pad of hydrous magnesium silicate, the filter pad washed with dichloromethane and the filtrate evaporated. The residue is crystallized from ethyl acetate to give 0.215 g of white crystals, m.p. 125°-132° C.

Workup

  1. customThe organic layer is separated
  2. washwashed with 15 ml each of 2N citric acid, 1M NaHCO3, brine
  3. dry with materialdried (Na2SO4)
  4. filtrationThe solution is filtered through a thin pad of hydrous magnesium silicate
  5. washthe filter pad washed with dichloromethane
  6. customthe filtrate evaporated
  7. customThe residue is crystallized from ethyl acetate

Sources & evidence

ORD record
ord-63e1c9b481ed4246bb08c4ce494e0ec1
Source dataset
uspto-grants-1997_08
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05654297

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes