Phosphorus oxychloride → 4-Chloro-6-iodo-2-(trifluoromethyl)quinazoline
Reaction equation
[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]([F:15])([F:14])[F:13])[NH:6][C:5]2=O.O=P(Cl)(Cl)[Cl:19]>>[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]([F:15])([F:14])[F:13])[N:6]=[C:5]2[Cl:19]Participants
3
Procedure
6-iodo-2-trifluoromethyl-3H-quinazolin-4-one (3.1 g, 9.1 mmole) was mixed with 20 mL of POCl3, heated to reflux for 3 h, removed most of unreacted POCl3 under vacuo. The residue was extracted with 15 mL of NaHCO3 (sat) and 200 mL of ether, ether layer was dried with MgSO4 and concentrated to give the light yellow solid 3.05 g, mp 145°-146° C., MS (CI): m/z 359 (MH)+.
Workup
- temperatureheated
- temperatureto reflux for 3 h
- customremoved most of unreacted POCl3 under vacuo
- extractionThe residue was extracted with 15 mL of NaHCO3 (sat) and 200 mL of ether, ether layer
- dry with materialwas dried with MgSO4
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-1c2c0e41765540e09c1d2ad3da6ceec5
- Source dataset
- uspto-grants-1997_08
- Patent number
- US05658902
Reaction notes
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