Allyl bromide → 2-(2-Propen-1-ylthio)pyrazine
Reaction equation
[SH:1][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.[CH2:8](Br)[CH:9]=[CH2:10]>C(N(CC)CC)C>[CH2:10]([S:1][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1)[CH:9]=[CH2:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
6.57 g of 2-mercaptopyrazine prepared in Reference Example 1 was dissolved in 80 ml of dimethylformaind and 8.6 ml of triethylamine was added thereto. 6.84 ml of allyl bromide was added to the solution and the mixture was stirred at 50° C. for 2 hours. 500 ml of ice water was added to the reaction solution and the resulting mixture was extracted with diethylether and concentrated. The residues were distilled under vacuum to give 7.85 g(85%) of oily pale yellow liquid.
Workup
- additionwas added
- extractionthe resulting mixture was extracted with diethylether
- concentrationconcentrated
- distillationThe residues were distilled under vacuum
Sources & evidence
- ORD record
- ord-641f590ead084f438b6faee712ba37ba
- Source dataset
- uspto-grants-1997_08
- Patent number
- US05658913
Reaction notes
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