3-Bromo-1-propanol → 1-Pyrrolidinepropanol

HRID 225758

Reaction equation

HRID 225758 reaction equation
Br[CH2:2][CH2:3][CH2:4][OH:5].[NH:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1>C1(C)C=CC=CC=1>[N:6]1([CH2:2][CH2:3][CH2:4][OH:5])[CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 123083-Bromo-1-propanolHCID 31268Pyrrolidine

Product 1

HCID 2093421-Pyrrolidinepropanol

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3-Bromopropan-1-ol (27.3 mL, 302 mmol) was added to a solution of pyrrolidine (47.2 g, 655 mmol) in toluene (1000 mL) and the mixture was stirred at room temperature for 48 hours. The reaction mixture was then filtered and the filtrate was evaporated under reduced pressure. The residue was distilled and the title product was obtained as a colourless liquid at 100° C./7 mmHg, (23.1 g, 59%).

Workup

  1. filtrationThe reaction mixture was then filtered
  2. customthe filtrate was evaporated under reduced pressure
  3. distillationThe residue was distilled

Sources & evidence

ORD record
ord-2ac62587795a42abb14e610714f0697f
Source dataset
uspto-grants-2009_07
Patent number
US07557121B2

Linked notes

Loading…