Reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH2:10]([C:12]([CH2:21][CH3:22])([C:18]([OH:20])=[O:19])[CH:13]([OH:17])C(O)=O)[CH3:11].N1CCCCC1.C(O)(=[O:31])C>CCOCC.C1C=CC=CC=1>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[CH:22][CH2:21][C:12]([CH2:10][CH3:11])([C:13]([OH:17])=[O:31])[C:18]([OH:20])=[O:19]Participants
Procedure
A 500-ml three-necked round flask (Dean & Stark) equipped with a stirring bar, a Dimroth condenser and a thermometer was charged with 74.0 g (400 mmol) of 2-bromobenzaldehyde, 70.48 g (440 mmol) of diethylmaloic acid, 1.6 ml of piperidine, 4.8 ml of acetic acid and 80 ml of benzene. The mixture was subjected to azeotoropic dehydration for 7 hours in an oil bath of 110° C. under a nitrogen atmosphere. After the reaction was completed, the reaction mixture was cooled to room temperature and 300 ml of ether was added, followed by washing with 100 ml of water two times. The organic phase was dried over anhydrous Na2SO4. The solvent was concentrated under reduced pressure and the concentrate of a orange liquid was distilled under reduced pressure to obtain 117.2 g of the desired product as a yellow liquid (yield: 90%).
Workup
- customA 500-ml three-necked round flask (Dean & Stark) equipped with a stirring bar
- washby washing with 100 ml of water two times
- dry with materialThe organic phase was dried over anhydrous Na2SO4
- concentrationThe solvent was concentrated under reduced pressure
- concentrationthe concentrate of a orange liquid
- distillationwas distilled under reduced pressure
Sources & evidence
- ORD record
- ord-197190ed1ca54641b6e7861308ae883a
- Source dataset
- uspto-grants-1997_08
- Patent number
- US05658997
Linked notes
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