Urea → 6-Chloro-1-cyclohexyl-1H-benzimidazol-2-ol
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([NH:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:3]=1.N[C:17](N)=[O:18]>CC1C=CC(C)=C(C)C=1C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][C:17](=[O:18])[N:9]([CH:10]3[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]3)[C:4]=2[CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 4.5 g of the compound obtained in Step B), 2.5 g of urea and 10 ml of 1,2,3,4-tetramethylbenzene is heated to 170°-180° C. for 90 minutes.
Workup
- temperatureis heated to 170°-180° C. for 90 minutes
Sources & evidence
- ORD record
- ord-aa6bde9ec99247d4b200c81a2bc232ea
- Source dataset
- uspto-grants-1997_08
- Patent number
- US05661169
Reaction notes
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