[SH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6](=[O:12])[CH2:5]2.Cl[C:14]1[S:15][C:16]([C@@:19]2([OH:26])[CH2:24][CH2:23][O:22][C@@H:21]([CH3:25])[CH2:20]2)=[CH:17][N:18]=1>CN1C(=O)CCC1>[OH:26][C@:19]1([C:16]2[S:15][C:14]([S:1][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([CH3:11])[C:6](=[O:12])[CH2:5]4)=[N:18][CH:17]=2)[CH2:24][CH2:23][O:22][C@@H:21]([CH3:25])[CH2:20]1Using an analogous procedure to that described in Example 26 except that NMP was used in place of DMF as reaction solvent, 5-mercapto-1-methylindolin-2-one was reacted with (2S,4R)-4-(2-chlorothiazol-5-yl)-4-hydroxy-2-methyltetrahydropyran to give (2S,4R)-4-hydroxy-2-methyl-4-[2-(1-methyl-2-oxoindolin-5-ylthio)thiazol-5-yl]tetrahydropyran in 27% yield, m.p. 140° C.;
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