Hydrochloric Acid → 2-Methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine hydrochloride
Reaction equation
[CH3:1][CH:2]1[N:7]([C:8]2[S:12][N:11]=[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:9]=2)[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:26]>CO>[ClH:26].[CH3:1][CH:2]1[CH2:3][NH:4][CH2:5][CH2:6][N:7]1[C:8]1[S:12][N:11]=[C:10]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:9]=1Participants
4
Procedure
To tert-butyl 3-methyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxylate (6.70 g, 18.6 mmol) was added a solution of 2N hydrogen chloride in methanol (400 ml) and the mixture was stirred at room temperature for 12 hours, and the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of ether and methanol to obtain the desired product (4.54 g, 82.2%) as a solid.