Methyl iodide → 1-Bromo-2,4-difluoro-3-methoxybenzene
Reaction equation
[OH:1][C:2]1[C:3]([F:10])=[C:4]([Br:9])[CH:5]=[CH:6][C:7]=1[F:8].[C:11](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH3:11][O:1][C:2]1[C:3]([F:10])=[C:4]([Br:9])[CH:5]=[CH:6][C:7]=1[F:8]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
A quantity of 3.7 g of 3-hydroxy-2,4-difluoro-bromobenzene is dissolved in 25 ml of acetone and 2.5 g of potassium carbonate is added followed by 2.2 ml of methyl iodide. The mixture is stirred at 20° C. for 6 hours and the solvent evaporated. After addition of dichloromethane, the suspension is filtered. Evaporation of the solvent affords the desired product.
Workup
- customthe solvent evaporated
- additionAfter addition of dichloromethane
- filtrationthe suspension is filtered
- customEvaporation of the solvent
Sources & evidence
- ORD record
- ord-6d51ffa0023a4bd0adeaeaf9ff6c2a84
- Source dataset
- uspto-grants-2001_12
- Patent number
- US06329391B1
Reaction notes
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