3-Aminopyridine → HCID 178500765, compound

HRID 226970

Reaction equation

HRID 226970 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4]([C:8](=[O:17])[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]=1)=[CH:5]OC.[NH2:19][C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1>>[CH3:1][O:2][C:3](=[O:18])[C:4]([C:8](=[O:17])[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]=1)=[CH:5][NH:19][C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 100093-AminopyridineHCID 668792722-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester

Product 1

HCID 178500765HCID 178500765, compound

Procedure

1g (4.02 mmol) of the crude 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester and 0.38 g (4.02 mmol) of 3-aminopyridine were heated neat at 100° C. for 2 h. The product crystallized upon cooling the reaction to rt to yield 1.12 g of 2-(3,4-Dimethyl-benzoyl)-3-(pyridin-3-ylamino)-acrylic acid methyl ester as brown crystalline solid.

Workup

  1. customThe product crystallized
  2. temperatureupon cooling
  3. customthe reaction to rt

Sources & evidence

ORD record
ord-a491c61e6e2641a79999bf1a6eea0aaf
Source dataset
uspto-grants-2009_07
Patent number
US07557213B2

Linked notes

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