2-Amino-6-methylpyridine → HCID 178500754, compound

HRID 226974

Reaction equation

HRID 226974 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4]([C:8](=[O:17])[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]=1)=[CH:5]OC.[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[N:21]=1>>[CH3:1][O:2][C:3](=[O:18])[C:4]([C:8](=[O:17])[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]=1)=[CH:5][NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[N:21]=1

Participants

3

Reactant 2

HCID 157652-Amino-6-methylpyridineHCID 668792722-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester

Product 1

HCID 178500754HCID 178500754, compoundYield 171.8%

Procedure

Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.50 g (2.01 mmol) of the crude 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester and 0.22 g (2.01 mmol) of 2-amino-6-picoline to yield 1.12 g of 2-(3,4-Dimethyl-benzoyl)-3-(6-methyl-pyridin-2-ylamino)-acrylic acid methyl ester as brown crystalline solid.

Sources & evidence

ORD record
ord-04461f3ba2c0457ab0fff7293d61ae64
Source dataset
uspto-grants-2009_07
Patent number
US07557213B2

Linked notes

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