HCID 178500754, compound → 3-(3,4-Dimethyl-benzoyl)-7-methyl-1H-[1,8]naphthyridin-4-one

HRID 226975

Reaction equation

HRID 226975 reaction equation
CO[C:3](=[O:24])[C:4]([C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[C:17]([CH3:22])[CH:16]=1)=[CH:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[N:8]=1>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH3:22][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][C:18]=1[CH3:21])[C:14]([C:4]1[C:3](=[O:24])[C:12]2[C:7](=[N:8][C:9]([CH3:13])=[CH:10][CH:11]=2)[NH:6][CH:5]=1)=[O:23]

Participants

3

Reactant 1

HCID 178500754HCID 178500754, compound

Product 1

HCID 577546333-(3,4-Dimethyl-benzoyl)-7-methyl-1H-[1,8]naphthyridin-4-oneYield 62%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

Experimental conditions analogous to those described for Step 2 of Example 1 were used with 0.59 g (1.82 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-(6-methyl-pyridin-2-ylamino)-acrylic acid methyl ester in 30 mL of diphenyl ether to yield 0.33 g of 3-(3,4-Dimethyl-benzoyl)-7-methyl-1H-[1,8]naphthyridin-4-one as a brown solid.

Sources & evidence

ORD record
ord-9d3b8fdd93c247c9b0a0ecd481dbd9bb
Source dataset
uspto-grants-2009_07
Patent number
US07557213B2

Linked notes

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