p-Toluenesulfonic acid → Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate
Reaction equation
[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH:6](C(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 5.1 g of diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate were added 20 ml of water and 30 mg of p-toluenesulfonic acid, followed by heating and refluxing for 2.5 hours. After cooling, the mixture was extracted with diethyl ether. The extract was dried over magnesium sulfate and concentrated to give 3.3 g of ethyl 2-methyl-3,4,6-trifluorobenzoylacetate.