Hydrochloric Acid → 1,4-Diazepan-2-one hydrochloride

HRID 227247

Reaction equation

HRID 227247 reaction equation

[O:1]=[C:2]1[NH:8][CH2:7][CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:16]>O1CCOCC1>[ClH:16].[NH:8]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][C:2]1=[O:1]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid

HCID 21962087tert-Butyl 3-oxo-1,4-diazepane-1-carboxylate

Product 1

HCID 234475441,4-Diazepan-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Compound from Step B was treated with 4 N hydrogen chloride in dioxane at ambient temperature for 2.5 h. Concentration gave the title compound.

Workup

concentrationConcentration

Sources & evidence

ORD record: ord-9334e80c14c045b58a60d9f0a1165788
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07560455B2

Linked notes

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