Acetonitrile → HCID 117974232, compound
Reaction equation
[CH3:1][NH:2][C:3]1[C:8]([NH2:9])=[CH:7][C:6]([C:10]([F:13])([F:12])[F:11])=[CH:5][N:4]=1.C1N=CN([C:19](N2C=NC=C2)=[O:20])C=1.C(#N)C>O>[CH3:1][N:2]1[C:3]2=[N:4][CH:5]=[C:6]([C:10]([F:13])([F:11])[F:12])[CH:7]=[C:8]2[NH:9][C:19]1=[O:20]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
A mixture of 1.91 g of N2-methyl-5-trifluoromethylpyridine-2,3-diamine, 3.24 g of carbodiimidazole and 10 ml of acetonitrile was stirred at 50° C. for 1 hour and at 80° C. for 2 hours. Water was poured into the cooled reaction mixture, and the precipitated crystal was obtained by filtration and dried to obtain 2.0 g of 3-methyl-6-trifluoromethyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one.
Workup
- customthe precipitated crystal was obtained by filtration
- customdried
Sources & evidence
- ORD record
- ord-4ea84d746c984934bd4efb551631caed
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09120792B2
Reaction notes
Loading…